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Targeting the Nrf2HO-1 axis has been considered as a key pathway regulating cellular inflammation and oxidative stress levels (Chen-Roetling and Regan, 2017

Since the cytoplasmic vacuolation may mimic microvesicular fatty change, a descriptive diagnosis of cytoplasmic vacuolation is recommended in the absence of electron microscopy or special immunostaining

Oxidative stress and toxin buildup

NAFLD appears to be more frequent in industrialized countries, its global prevalence is about 25% and varies across different geographical areas, being higher in Middle East and South America and lower in Africa (33)

Several studies have shown that supplementing with L-carnitine can diminish the above symptoms in adult dialysis patients, but whether children can benefit from L-carnitine remains unclear