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The hypothalamus reduces GHRH, and the pituitary reduces GH secretion

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The exact mechanism responsible for the higher AUC of metformin with oral semaglutide and dulaglutide is unknown but may relate to a delay in gastric emptying or differences in study design

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Staying hydrated addresses both nausea and constipation

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As an investigational triple-receptor agonist targeting the GLP-1, GIP, and glucagon receptors, it is being studied in metabolic and weight-loss research contexts

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