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Complementing this, a 2024 review on NLRP3 therapeutics in DR highlighted new inhibitors like tonabersat, which block P2X7R-mediated ATP signaling in retinal microglia, decreasing IL-1/IL-18 release and microglial polarization to hinder progression from early NPDR to proliferative stages (44)

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Siddiquee KAZ, Arauzo-Bravo MJ, Shimizu K