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In theory, this suggests GLP-1 drugs could help calm inflammatory skin diseases, including eczema, by: Reducing systemic inflammation Improving insulin resistance (which is linked to some eczema subtypes) Supporting a healthier gut-skin axis (via weight loss and metabolic balance) However, the clinical evidence is not yet conclusive

As above-mentioned, TMAO increases intracellular ROS, and ROS activates NF-B signaling by triggering the IKK complex, leading to IB phosphorylation and degradation

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