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By contrast, a claim that an oral or enteric-coated peptide acts locally in the digestive tract is at least biologically coherent, because the low absorption that defeats systemic use is irrelevant when the target is the gut itself
Semaglutide has a one-week half-life allowing once-weekly dosing, but some patients report variations in hunger levels throughout the week
doi: 10.1016/j.cca.2019.11.003 155 De LeoVla MarcaAPetragliaF
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