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According to Roy Moore, senior healthcare research and data analyst at information services agency Clarivate, Cignas national plan used to list Zepbound and Wegovy as excluded drugs and Mounjaro and Ozempic as not covered. RELATED: Does Aetna cover Zepbound

Concurrently, TNF-, IL-1, and IL-6 activate NF-B, JAK/STAT, and MAPK pathways, enhancing protease expression and suppressing myogenesis (He et al., 2025)

The authors acknowledge this limitation

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1 This concern is especially relevant with the growing use of GLP-1 medications, which are effective for both diabetes glycemic control and obesity management