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Exenatide, a short-acting GLP-1-RA has shown beneficial effects on systemic inflammation in clinical studies, both acutely and by chronic treatment (8,36), but whether those effects translate into CV RR remains to be demonstrated in a CV outcome trial

However, it is critical to distinguish between biological activity and therapeutic efficacy: these biomarker changes did not translate into any measurable clinical benefit, and should therefore be interpreted as evidence of limited central engagement rather than as support for the prevention-dominant hypothesis

Rotating injection sites and applying gentle pressure post-injection can minimise discomfort

E., Dobson, R

McBeth notes a troubling trend in her practice