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Cycling Protocols for Long-Term Use Extended peptide use requires cycling to prevent receptor desensitization, allow the body natural recovery periods, and reduce the theoretical risks associated with prolonged administration
3,417 adults randomized to cagrilintide 2.4 mg + semaglutide 2.4 mg, cagrilintide alone, semaglutide alone, or placebo for 68 weeks
Over-treatment can lead to irritation and compromise results
Daniel Chille Oh, that is a good question I have to recall
The analysis was done after the fact rather than as a primary endpoint, and the clocks were measured in blood, so they track systemic aging rather than the brain in particular
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