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Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

NAT2 protein is present mainly in the liver (Grant et al., 1990) and intestine (Hickman et al., 1998)

Radiation enteropathy-related depression: a neglectable course of disease by gut bacterial dysbiosis

it causes transient mood and memory impairments accompanied by elevated inflammatory cytokines in the CNS [63]

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