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This warning is not based on human epidemiology alone but largely originates from rodent toxicology studies , where GLP-1 receptor activation led to: Increased calcitonin secretion C-cell hyperplasia C-cell adenomas and carcinomas in rats/mice These findings have been consistently observed across multiple GLP-1 receptor agonists
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Activities that engage the core and promote general movement are beneficial
95% CI 1.07 to 0.38
For example, a phase 2 trial showed that tirzepatide, a dual Gastric Inhibitory Polypeptide (GIP) and GLP-1 RA, significantly improved MASH
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