Cost may affect how long a person can stay on it
A Lithium GLP-1 Interaction More evidence of a serious drug interaction STUDY: Patarroyo-Rodriguez LP et al, J Clin Psychopharmacol 2026 STUDY TYPE: Case report FUNDING: National Center for Advancing Translational Science (NCATS) Background GLP-1 and GIP/GLP-1 receptor agonists like tirzepatide (Mounjaro, Zepbound) cause nausea, vomiting, and dehydration, especially during dose escalation
This in turn enables the activation of defense signaling proteins and transcription factors which helps to establish innate immune memory (Lindermayr and Yildirim, 2025)
Retatrutide is a triple agonist that adds glucagon receptor activity to the GLP-1/GIP profile
However, if you are committed to maintaining your new, lower weight, the effects on your face will likely stay the same