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Initially investigated for its potential to treat neurodegenerative diseases like Alzheimers and Parkinsons, this small synthetic peptide is known to bind with high affinity to hepatocyte growth factor (HGF) and its receptor c-Met, thereby promoting neuronal differentiation, dendritic branching, and synaptic plasticity
This prolongs its half-life by up to 15 hours but reduces the affinity to the insulin-like growth factor 1 receptors
doi: 10.1016/j.neuropharm.2014.07.012, 28
Neither is sufficient alone, neither makes the other redundant
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