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The likely mechanism involves GLP-1-mediated changes to gut-derived hormonal signals affecting bone remodeling, compounded by the fact that significant weight loss removes a key mechanical stimulus that keeps bone dense and strong
Low Starting Amount (Research) Amount per measure: 250 mcg 7.5 units (0.075 mL) on a U-100 insulin syringe Schedule: Once weekly in research models (same day each week) Study length: 16+ weeks (raise the amount slowly) Weeks 14 use the starting amount
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