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GLP-1 medications can indirectly affect several of these factors by reducing appetite and overall calorie consumption
Unanswered Questions Regarding Weight Loss Mechanisms: Perspectives to Preclinical Research The exact mechanisms underlying the weight loss are still not clear, especially in light of the enhanced effects seen with multi-agonism, despite the large number of incretin agonists presently undergoing clinical trials and their remarkable effectiveness in managing obesity and T2DM [5, 14, 146, 147]
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4 GLP-1RAs are FDA-approved for treating type 2 diabetes, which may be linked to potential GLP-1 impairment and slowed GLP-1 activation post-prandial
3f), whereas mechanical allodynia was dose-dependently alleviated in the groups treated with exendin 939 (5 or 10 g) or BCTC (0.5 g), a widely used TRPV1 inhibitor 40
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