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In rats fed a high-fat-diet, metformin (200 mg/kg) was shown to reduce glucose absorption by inhibiting the expression of sodium glucose cotransporter-1 in the upper small intestine [36]

Grover K, Koblova A, Pezacki AT, Chang CJ, New EJ

Growth hormone release occurs predominantly during deep sleep phases, making 7-9 hours of quality rest essential for tissue repair and recomposition

Other medicines may need to be adjusted or restarted

The dose is gradually increased according to the prescribed treatment schedule, with each dose level maintained for approximately 30 days before escalation