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In conclusion, on the basis of these studies, this review speculated that there may be two mechanisms of ferroptosis leading to obesity: (i) In the autonomic nervous system, vagus and parasympathetic nerves in some organs or tissues may be affected by ferroptosis and become dysfunctional, while the inflammatory factors released from adipocytes lead to excessive sympathetic activation and hypothalamic neuronal ferroptosis which promotes the development of obesity through a series of processes
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However, whether longer use of multi-agonists can induce sustained improvements in hard outcomessuch as cardiovascular events, liver cirrhosis, or mortalityremains to be determined
