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A 2025 meta-analysis of 22 randomized trials found that, on average, about 25% of the weight lost during GLP-1 therapy was from lean mass

Participants treated with liraglutide (239), semaglutide (240), or tirzepatide (200) in the clinical trials had a percent reduction in fat mass approximately three times greater than the reduction in lean mass, leading to an overall improvement in body composition

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doi:10.1016/s0015-0282(02)04679-4 Retrieved from: Sinatra, Stephen, M.D., F.A.C.C., (1999)

Preventing new episodes of bipolar disorder in adults: Systematic review and meta-analysis of randomized controlled trials