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By increasing and prolonging active incretin levels, JANUVIA increases insulin release and decreases glucagon levels in the circulation in a glucose-dependent manner

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These properties have established it as a widely used reference compound in studies examining melanocortin receptor signaling, receptor selectivity, ligand-receptor interactions, and comparative pharmacology among melanocortin receptor agonists and related peptide analogues.

Am J Physiol 259:G524G529 Hara KY, Kiriyama K, Inagaki A, Nakayama H, Kondo A (2012) Improvement of glutathione production by metabolic engineering the sulfate assimilation pathway of Saccharomyces cerevisiae

[PMID: 8440736] PubMed record related to this compound for laboratory literature review