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The patient was referred to endocrinology and started on tirzepatide 2.5 mg subcutaneous once weekly for 4 weeks, then increased to 5 mg once weekly as per standard dosing protocol
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Lower doses produced more modest reductions: 4 mg dose: approximately 8.7% mean weight reduction 0.5 mg dose: approximately 2.0% mean weight reduction Placebo: a small mean weight gain of approximately 2.0% Readers should note that these figures are drawn from a single phase 2 trial with a relatively small sample size and 24-week duration
Enzyme inhibition assays with recombinant human GSTP1, kinetic analysis, molecular docking, and molecular dynamic simulations were employed
PMID 26060103
