Rev Med Suisse 19:756760 Armamento-Villareal R, Aguirre L, Waters DL, Napoli N, Qualls C, Villareal DT (2020) Effect of aerobic or resistance exercise, or both, on bone mineral density and bone metabolism in obese older adults while dieting: a randomized controlled trial
Fat browning refers to the high plasticity of white fat cells, which can be transformed into beige fat cells with many similar morphological and functional characteristics to brown fat cells under the stimulation of exercise, cold exposure, adrenergic receptor stimulation, and other factors [83]
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Schedule (Once Weekly Injection) Upper limit: 12 mg per week is the highest dose used in the major published clinical trials (Phase 2 obesity, Phase 2 type 2 diabetes, and the Phase 3 TRIUMPH-4 and TRANSCEND-T2D-1 studies)
Despite the increased short-term risk, the long-term impact remains unclear, and further studies are needed to fully understand the underlying mechanisms