There is reduced fetal weight and kind of reduced ossification of the bones and potentially congenital abnormalities in the offspring. These problems have not been observed in humans, but there have also been no deliberate studies of their effects during pregnancy
In a 12-month randomised clinical trial, spermidine supplementation was found to be safe, with no significant adverse effects reported
in: PubMed | Google Scholar | 1 Yale University, Department of Pediatrics, New Haven, Connecticut, USA
Patient-reported outcomes Carefully selected patient-reported outcome (PRO) instruments (standardised questionnaires designed to understand the patient experience) were administered at baseline and at 40 or 52 weeks across the SURPASS clinical trial programme (Boye et al, 2023)
Avoid driving or using machines if you get any signs of low blood sugar, e.g., headache, drowsiness, weakness, dizziness, feeling hungry, confusion, irritability, feast heartbeat and sweating