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In a phase 2 trial involving people with obesity, the 12 mg weekly dose of retatrutide resulted in a placebo-adjusted mean weight reduction of 22.1% after 48 weeks of treatment

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Among the 37 patients initially put on naltrexone-bupropion, 11 of them (29.7%) continued naltrexone-bupropion up to 18 months, 9 of them (24.3%) continued up to 24 months and 8 of them (21.6%) continued up to 30 months

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The 2024 EMA review of GLP-1 receptor agonists found no causal link to suicidality, and ongoing FDA analyses have not confirmed one either