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Small animal rat model Six-week-old male Sprague-Dawley rats were obtained from Shanghai Lab, Animal Research Center Co
They also recommend them as a possible initial treatment in those with diabetes and certain comorbidities such as obesity, chronic kidney disease and prior significant cardiovascular events
Trials with older GLP-1 drugs (liraglutide, exenatide) including the large ADJUNCT ONE and ADJUNCT TWO studies showed modest HbA1c improvements of 0.10.7%, meaningful weight loss, and lower insulin requirements, but also raised early concerns about hypoglycemia and ketosis that kept enthusiasm in check for years
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