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Additionally, in RNAi processes, the 5 nucleobase affects the binding activity of AGOs to siRNA, thus reducing target cleavage activity

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In activated T cells, flux through the oxidative PPP increases nearly 10-fold, but chemical inhibition of G6PD can markedly decrease this and, as a result, impair T cell activation and decrease production of pro-inflammatory interferon-gamma (IFN-) (55)

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