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However, its metabolic conversion by gut microbiota into TMAO raises significant concerns due to the association of elevated TMAO levels with cardiovascular diseases like atherosclerosis, MI, stroke, and HF

Reutens AT, Jandeleit-Dahm K, Thomas M et al (2020) A physician-initiated double-blind, randomised, placebo-controlled, phase 2 study evaluating the efficacy and safety of inhibition of NADPH oxidase with the first-in-class Nox-1/4 inhibitor, GKT137831, in adults with type 1 diabetes and persistently elevated urinary albumin excretion: protocol and statistical considerations

SOUL: CVOT 13 Study design: A randomized, international, double-blind, parallel-group, placebo-controlled, event-driven, superiority phase 3b trial in adults with T2D and established atherosclerotic cardiovascular disease, CKD, or both

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