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The clinical appearance is one of the brown to black spots or macules, with a histopathological increase in melanin in the basal cell layer of the oral epithelium and melanin incontinence in the upper portion of the lamina propria, but without an increase in the number of melanocytes [11, 39, 40]

Experimental studies in both animals and humans have tried to confirm the findings from observational studies and reported that CLA exhibits numerous health benefits including anti-obesity, anti-carcinogenic, hypotensive, hypoglycemic, and immunomodulatory effects (table 2)

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Fox Foundation provided study funding

Does carnitine administration improve the symptoms attributed to anticonvulsant medications