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Instead, research points to activity across multiple interconnected systems, including modulation of the nitric oxide (NO) system, upregulation of growth factor expression (notably VEGF, EGF, and FGF pathways), promotion of angiogenesis, and activation of the FAK-paxillin signalling pathway involved in cell migration and tissue organisation

A 2026 survey from Business Group on Health found that nearly eight in 10 employers said GLP-1s were increasing company healthcare costs, with many weighing stricter coverage rules as medical and pharmacy spending rise

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