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Notably, GLP-1R has been reported to be absent in the VMH based on rat immunochemistry and non-human primates ISH studies, warranting caution when extrapolating these findings across species [66,67]

Shen Y, Tian M, Zheng Y et al (2016) Stimulation of the hippocampal POMC/MC4R Circuit alleviates synaptic plasticity impairment in an Alzheimer

The GLP-1 receptors may already be partially desensitized from semaglutide use, but the GIP receptors are "fresh" and fully responsive

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