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Central nervous system involvement is further supported by GLP-1 production in caudal brainstem neurons, key integrators of vagus nerve-mediated gut-brain signaling 53,54,55,56
The integrity of the hippocampus is important for spatial and episodic memory, and that it is one of the first brain regions affected in AD (42)
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The limited number of treatments able to significantly reduce weight, as well as the risk of renewed weight gain from 6 months after the end of intervention, have been an obstacle for considering pharmacological treatment for obesity in patients with PsO or HS.15 Approved and marketed drugs in SpainOrlistat Orlistat is an inhibitor of the gastric and pancreatic lipases that block hydrolysis of triacyl glycerides and absorption of fatty acids through the intestinal endothelium
Such designs will also help refine the proposed U-shaped effect on sperm function, which currently rests on limited and sometimes inconsistent evidence [38]
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