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141 This prolonged duration may be driven by albumin binding to the fatty acid residues of GLP-1 RAs and their ability to escape protease metabolism due to amino acid substitutions (Figure 1)
Mol Ther Nucleic Acids (2020) 23:61428
Burgess S
Tulsa World
Discussion This is the preclinical study investigating the utility of [ 18 F]FB(ePEG12)12-exendin-4, a novel PEGylated exendin-4-based probe, in PET/CT imaging for detecting insulinoma using both INS-1 xenograft mouse models and Pdx1-Cre;Trp53 R172H ;Rb f/f mice, a novel multiple panNEN mouse model, with developed endogenous insulinoma and glucagonoma
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