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Papke RL, Stokes C, Damaj MI, Thakur GA, Manther K, Treinin M, Bagdas D, Kulkarni AR, Horenstein NA (2018) Persistent activation of 7 nicotinic ACh receptors associated with stable induction of different desensitized states
This is the same mechanism targeted by topical brightening agents, delivered systemically instead, and the effect is best understood as a gradual, cumulative brightening support across a series rather than an overnight change