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Imboden M, Rochat T, Brutsche M, Schindler C, Downs SH, Gerbase MW, et al

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Side Effects Comparison# Retatrutide Side Effects# Phase 2 trial data revealed: Gastrointestinal : Nausea (24-46%), diarrhea (16-26%), vomiting (9-20%), constipation (6-16%) Heart rate : Small mean increase (2-4 bpm) potentially related to glucagon receptor activation Injection site reactions : Mild and transient Hepatic : Transient elevations in liver enzymes observed Discontinuation rate : 6-10% due to adverse events in Phase 2 The glucagon receptor component introduces a unique side effect profile compared to GLP-1-only or GIP/GLP-1 dual agonists

Metabolic 2025-06-26 Amylin , a 37-amino-acid peptide hormone co-secreted with insulin by pancreatic -cells, activates calcitonin receptor complexes (CT/RAMPs) in the nucleus tractus solitarius (NTS) of the hypothalamus to suppress appetite and delay gastric emptying by approximately 50%, thereby enhancing satiety [1]

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