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For healthy athletes, however, evidence for broad improvements in body composition or aerobic performance is mixed

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The H-bond network is only observed for OCTN2 in the occluded conformation and is absent in the inward-facing conformation, supporting that the network helps to stabilise a kinked conformation of TM11 that packs against TM2

In addition, upregulation of IGFBP2 expression may promote IGF-IR/Akt activation thereby conferring resistance to BRAF and MEK inhibitors [131]

Leibetseder, 1995