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The decision to initiate pharmacotherapy should involve shared decision-making, considering individual patient values, preferences, treatment goals, and cost considerations, as these medications can be expensive and may face insurance coverage limitations

Alternative dosing strategies for tirzepatide may reduce dose-related side effects

Decision-makers in charge of employee health plans agree that coverage for GLP-1s could keep employees healthier

men, the authors also note no heterogeneity in effect on KCCQ-CSS (8.1- and 5.5-point placebo-corrected improvement, respectively, interaction p=0.43) or six-minute walking distance (16 m and 15 m placebo-corrected improvement, respectively, interaction p=0.76)