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[25] Tretinoin, the all-trans retinoic acid isomer, diffuses through the stratum corneum and binds intracellular retinoic acid receptors (RAR-, , ), forming heterodimers with RXR that trans-activate genes governing keratinocyte differentiation, desmosomal degradation, and collagen synthesis

You can also try adding a solvent that increases solubility (as above)

Niacinamide One of my favorite ingredients

Glutathione is also present in the skin and can protect the skin from UV-induced oxidative stress

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