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For DNA to be replicated for new cells, both folate and vitamin B12 can be limiting factors

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doi: 10.3390/cells9020400 75 KodamaTTakedaKShimozatoOHayakawaYAtsutaMKobayashiKet al

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Excessive peritoneal iron accumulation leads to overproduction of reactive oxygen species (ROS)-a group of highly reactive chemicals formed from oxygen, which at high concentrations can damage DNA, RNA, proteins, and lipids within the cell (20)-and enhanced activation of nuclear factor kappa-B (NF-B), which, by promoting the expression of matrix metalloproteinases (MMPs), exacerbates inflammation, angiogenesis, and cell adhesion