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Another important variable not captured was whether and the degree to which participants received substance use disorder treatment after diagnosis during the study window (see below for information on study window determination)

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A 2023 case series in Headache: The Journal of Head and Face Pain (Robbins et al.) reviewed 847 patients starting semaglutide and found: 14% reported headaches during the first 16 weeks Of those, 23% noted clear positional worsening (worse lying down or worse standing, depending on individual CSF dynamics) 89% of positional headaches resolved by week 20 without intervention beyond hydration 2.1% required temporary dose reduction 0.4% discontinued due to intolerable headache The positional component is underreported because patients don't always connect the pattern