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Additional clinical considerations include: previous weight loss attempts (lifestyle modifications should generally be attempted first), cardiovascular risk profile, family history of medullary thyroid carcinoma (a contraindication for GLP-1 agonists), history of pancreatitis, current medications, mental health status, and pregnancy planning (GLP-1 agonists must be discontinued at least 2 months before conception)
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Side effects, contraindications, and personal health history all need to be carefully considered
Few people witness severe fatigue along with morning stiffness without even realising that an inflammatory process is already underway
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