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As these fat pads shrink, the overlying skin may not retract sufficiently, especially in older adults or those with reduced skin elasticity, resulting in hollowing of the cheeks, temples, and under-eye areas, alongside increased prominence of nasolabial folds and jowls
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10.1111/j.1749-6632.2012.06574.x 11 Brigelius-FlohR.MaiorinoM
The anti-inflammatory effect of the probiotic Clostridium butyricum is the result of the induction of TGF- signaling in DC, which, in turn, induces Treg cells generation [34]
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