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An inverse correlation is observed between plasma PYY and BMD in populations with weight gain and obesity (decreased PYY and increased BMD) and in weight loss scenarios (increased PYY and decreased BMD), as observed in patients with anorexia and amenorrheic athletes [81]

This might be related to the glucagon 1-inducible protein P9, which induces GLP-1 secretion by activating GPCR-like downstream signals (83)

Semaglutide is a medication that is commonly used to treat type 2 diabetes and, more recently, to help with weight loss

Research shows that it significantly extends mouse lifespan

The principal mechanism described is that GLP-1 signaling exerts control over gustatory perception via peripheral and central mechanisms (163)