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While women with the shortest telomeres and low dietary intake of antioxidants, including beta-carotene, vitamin C, and E, showed a moderate increase in breast cancer risk, underlining the importance of an accurate dietary intake of antioxidants (Shen et al., 2009)

AMPK agonists inhibit ferroptosis by activating AMPK, which subsequently upregulates GPX4 expression and downregulates lipocalin-2 expression in vivo (63)

The findings published in The Lancet Diabetes & Endocrinology , along with results from a related clinical trial published concurrently, suggest that patients seeking to lose more weight can safely take a higher semaglutide dose than typically prescribed

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Future: Dedicated NASH Phase 3 Trial - NOT YET STARTED Status: Expected 2027-2030 (after obesity/diabetes approval) What This Would Include: Liver biopsy as PRIMARY endpoint NASH resolution as primary outcome Fibrosis improvement measurement Required for FDA approval specifically for NASH indication Why Wait