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Neha Agarwal I cane to laderma for plumping my lips

We didnt project well how many prescribers would put their patients on GLP-1s for weight loss, and the uptick was much bigger than we thought

Here's what they've said

Development of GLP-1MK-801 To safely harness the weight-lowering properties of NMDA receptor antagonism, we developed a targeting approach based on the hypothesis that conjugation of MK-801 to a GLP-1 analogue through a chemically cleavable disulfide linker would enhance the therapeutic potential of NMDA receptor antagonism in appetite-regulating brain regions enriched for GLP-1 receptors, while mitigating the adverse effects related to the non-restricted actions of MK-801

Prediction #2: More Emergency Room Visits Due to Adverse Effects In 2025, researchers published an analysis estimating approximately 24,499 emergency-room visits attributable to semaglutide adverse events in 2022 and 2023