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In an uncontrolled clinical trial in men with erectile dysfunction, 50 mg of DHEA per day for six months improved erectile function in 27 men with high blood pressure and 28 men with no known underlying condition, but not in 24 men with type 2 diabetes or six men with neurological disorders
Based on the profile of participants enrolled in retatrutide trials to date, the drug appears most relevant to adults living with obesity (BMI 30 kg/m) or those who are overweight (BMI 27 kg/m) with weight-related health conditions such as type 2 diabetes, hypertension, dyslipidaemia, or obstructive sleep apnoea
Free radicals can damage renal tubular cells and disrupt the function of sodium transporters, leading to sodium retention and increased blood volume, which further elevates blood pressure [82]
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This renders traditional pills largely ineffective for the deep cellular repair needed in RA
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