10.1210/en.2014-1675 56 HolscherC
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The underlying process that drives the diseases is the loss of synaptic activity, the loss of synapses, and finally, the loss of neurons (Picconi et al., 2012
However, establishing causality remains challenging: pancreatitis is multifactorial, and patients on GLP-1s often have comorbidities (obesity, diabetes, gallstones) that independently increase risk
This age-related decline correlates with diminished wound healing capacity, reduced collagen synthesis, and compromised tissue regenerationobservations that sparked decades of research into GHK-Cu's role in aging and tissue maintenance