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Currently, there are other dual GIPR/GLP-1R agonists available, such as GLP-1R/GR (glucagon receptor), GLP-1R/AR (amylin receptor), and GLP-1R/NPYR (peptide YY binds to neuropeptide Y receptors) [36, 115] and even triple agonists that can activate GIPR to treat obesity and T2DM

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These erectile function studies have established MT-II as the prototype centrally acting pro-erectile melanocortin agonist and provided the mechanistic framework for understanding how central MC4R activation produces peripheral erectile responses

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