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Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15

doi: 10.1016/j.biopha.2018.07.157 82 NagakannanPIslamMISultanaSKarimi-AbdolrezaeeSEftekharpourE

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