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Digestive Changes: Shifting the dose can sometimes lead to temporary changes in bowel habits, such as mild constipation or diarrhea, as the digestive system adjusts to the new timing

In practice, you will get slightly fewer doses than the math suggests

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Conversely, people who already present with high anhedonia, for instance, in the context of a depressive illness, may see their symptoms worsening when on GLP-1RAswhich could elucidate some of the studies reporting negative effects associated with these medications in mood and anxiety disorders

For semaglutide, that could mean starting at 0 } Potential Benefits of Microdosing GLP-1 Clinical trials have not specifically evaluated GLP-1 microdosing at sub-standard doses, and off-label lower-dose approaches have not been validated in randomized controlled trials