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Several next-generation programmes are exploring therapies designed to preserve lean muscle mass during weight loss, an increasingly important clinical objective as obesity therapies become more widely used

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Compared to the active state, ECL1 moves toward helix I by 5 when measured at the N-terminal tip of the helix (C of Q211), and ECL1 residue W214 is reoriented ~180 o from an outside-facing position to a position pointing towards helix I

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