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TNF- is a central link in the inflammatory cascade and can promote the release of other pro-inflammatory substances, thereby accelerating the inflammatory process (24)
Slowed Gastric Motility GLP-1 medications mimic the action of glucagon-like peptide-1, a hormone that: Enhances insulin secretion Suppresses glucagon release Delays gastric emptying Reduces appetite That delayed gastric emptying is a double-edged sword
Retatrutide further reduced plasma alanine aminotransferase and liver triglycerides, suggesting improvements in liver health [42]
Activation of AMPK in the hypothalamus results in altered fatty acid metabolism and increased mitochondrial fatty acid oxidation which ultimately results in increased release of NPY and AgRP leading to an increased desire for food intake
