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Semaglutide may act beyond weight losspotentially rewiring inflammation and adipose tissue function at the epigenetic level, the authors suggest

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Furthermore, 85.3% of semaglutide-treated participants achieved at least 10% weight loss, 61.8% achieved at least 15% weight loss and 47.1% achieved at least 20% weight loss, compared with 6.9%, 6.9% and 3.4%, respectively, in the placebo group

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Safety and side effects Both forms can cause nausea, vomiting, diarrhea, constipation, bloating, and reduced appetite, especially early in treatment or after dose increases such as moving up from Rybelsus 3 mg [1]